At least 40 women will die because they refused to take up the HPV vaccine last year according to the Irish Cancer Society.
Another 100 will need life-changing treatment and a further 1, 000 will require invasive therapy as a result.
Figures from the HSE show half of eligible schoolgirls declined the vaccine in the last academic year.
They claim a misinformation campaign has affected the uptake.
Brenda Corcoran from the HSE says figures from other countries show the vaccine does work.