The N80 between Bunclody and the turning for Clohamon has re-opened after a serious road crash yesterday morning.
A schoolbus and two cars were involved in the collision on the Enniscorthy side of Bunclody near the town cemetery.
A 21 year old woman was taken from the scene by helicopter to a Dublin hospital with what are described as very serious injuries.
While a 60 year old woman was taken to Wexford hospital with non life threatening injuries.
Up to 20 children were on the bus, believed to be from County Cavan.
None of the children were seriously injured and were treated for shock at the scene.
Gardai in Enniscorthy are appealing for witnesses or anyone with a dash cam to contact them.